What are the top 10 most significant developments in heart disease treatment globally?

1. Coronary artery bypass surgery: This procedure involves bypassing blocked or narrowed coronary arteries to restore blood flow to the heart muscle.

2. Angioplasty and stenting: This minimally invasive procedure involves threading a catheter with a balloon on its tip into blocked arteries, inflating the balloon to open the artery, and then placing a stent to keep it open.

3. Statins: These cholesterol-lowering drugs have been instrumental in reducing the risk of heart disease by lowering LDL cholesterol levels and reducing inflammation.

4. ACE inhibitors and ARBs: These medications are commonly prescribed to manage high blood pressure and improve heart function in people with heart disease.

5. Beta-blockers: These drugs help reduce heart rate and blood pressure, making them valuable in managing various heart conditions such as heart failure and certain arrhythmias.

6. Implantable cardioverter-defibrillators (ICDs): These devices are implanted in the chest to continuously monitor heart rhythms and deliver electrical shocks to restore normal heart rhythm in cases of dangerous arrhythmias.

7. Cardiac resynchronization therapy (CRT): This therapy involves placing a special pacemaker in the heart to help synchronize its contractions, improving heart function in people with heart failure.

8. Transcatheter aortic valve replacements (TAVR): This minimally invasive procedure involves replacing a diseased aortic valve by inserting a replacement valve through a catheter, avoiding the need for open-heart surgery.

9. Heart transplantation: This life-saving procedure involves replacing a failing heart with a healthy donor heart, generally reserved for those with end-stage heart failure.

10. Lifestyle modifications: While not a specific medical development, lifestyle changes such as maintaining a healthy diet, regular exercise, quitting smoking, and managing stress have been integral in preventing and managing heart disease.