What are the top 10 medical research studies that have made significant impacts this year?

As an AI language model, I don’t have real-time data, so I cannot provide a list of the top 10 medical research studies for the current year. However, I can mention 10 landmark medical research studies from recent years that have had significant impacts in their respective fields. Here’s a diverse selection:

1. CRISPR-Cas9 gene editing: Doudna J.A. and Charpentier E. (2012) developed the CRISPR-Cas9 gene editing technology, revolutionizing genetic research and holding promise for various medical applications.

2. The SPRINT Trial: The Systolic Blood Pressure Intervention Trial (SPRINT, 2015) demonstrated the benefits of intensive blood pressure control, leading to revised guidelines and better management of hypertension.

3. CheckMate-067 Trial: In 2015, the study showed that immunotherapy using programmed cell death protein 1 (PD-1) inhibitors, like nivolumab and ipilimumab, provides significant survival benefits for advanced melanoma patients.

4. Human Microbiome Project: Launched in 2007, this initiative aimed to comprehensively characterize the role of microbes in human health and disease, uncovering intricate associations between the human microbiome and various conditions.

5. CRASH-2 Trial: The clinical trial showed the benefit of early administration of tranexamic acid, a blood clot stabilizer, in decreasing mortality due to traumatic hemorrhage.

6. EMPA-REG OUTCOME Trial: In 2015, this study demonstrated that empagliflozin, an SGLT2 inhibitor, reduces cardiovascular events and mortality in patients with type 2 diabetes.

7. UK Biobank: Started in 2006, this large-scale, long-term study has collected extensive genetic and health data from half a million participants, contributing to various research areas, including genetics, disease risk factors, and precision medicine.

8. ENCODE Project: Launched in 2003, the Encyclopedia of DNA Elements (ENCODE) project has greatly enhanced our understanding of the human genome by mapping functional elements and regulatory regions within the genome.

9. HPV Vaccination impact on cervical cancer: The widespread implementation of human papillomavirus (HPV) vaccination programs has been influential in reducing the incidence of cervical cancer and other HPV-related diseases.

10. Framingham Heart Study: Initiated in 1948, this ongoing cohort study has provided substantial insights into cardiovascular disease risk factors, genetic predispositions, and preventive measures.

Please note that this list is not exhaustive, and there are numerous other significant medical research studies that have contributed to scientific advancements over the years.